IFITM3 and severe influenza virus infection. No evidence of genetic association.
Identifieur interne : 000142 ( Main/Exploration ); précédent : 000141; suivant : 000143IFITM3 and severe influenza virus infection. No evidence of genetic association.
Auteurs : M. L Pez-Rodríguez [Espagne] ; E. Herrera-Ramos [Espagne] ; J. Solé-Violán [Espagne] ; J J Ruíz-Hernández [Espagne] ; L. Borderías [Espagne] ; J P Horcajada [Espagne] ; E. Lerma-Chippirraz [Espagne] ; O. Rajas [Espagne] ; M. Briones [Espagne] ; M C Pérez-González [Espagne] ; M A García-Bello [Espagne] ; E. L Pez-Granados [Espagne] ; F. Rodriguez De Castro [Espagne] ; C. Rodríguez-Gallego [Espagne]Source :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 1435-4373 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de séquence d'ADN (MeSH), Espagne (MeSH), Femelle (MeSH), Fréquence d'allèle (MeSH), Grippe humaine (génétique), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Polymorphisme de restriction (MeSH), Protéines de liaison à l'ARN (génétique), Protéines membranaires (génétique), Prédisposition génétique à une maladie (MeSH), Réaction de polymérisation en chaîne (MeSH), Sujet âgé (MeSH), Techniques de génotypage (MeSH), Études cas-témoins (MeSH).
- MESH :
- génétique : Grippe humaine, Protéines de liaison à l'ARN, Protéines membranaires.
- Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Espagne, Femelle, Fréquence d'allèle, Humains, Jeune adulte, Mâle, Polymorphisme de restriction, Prédisposition génétique à une maladie, Réaction de polymérisation en chaîne, Sujet âgé, Techniques de génotypage, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Case-Control Studies (MeSH), Female (MeSH), Gene Frequency (MeSH), Genetic Predisposition to Disease (MeSH), Genotyping Techniques (MeSH), Humans (MeSH), Influenza, Human (genetics), Male (MeSH), Membrane Proteins (genetics), Middle Aged (MeSH), Polymerase Chain Reaction (MeSH), Polymorphism, Restriction Fragment Length (MeSH), RNA-Binding Proteins (genetics), Sequence Analysis, DNA (MeSH), Spain (MeSH), Young Adult (MeSH).
- MESH :
- chemical , genetics : Membrane Proteins, RNA-Binding Proteins.
- genetics : Influenza, Human.
- Adult, Aged, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotyping Techniques, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Sequence Analysis, DNA, Spain, Young Adult.
Abstract
Influenza virus infection (IVI) is typically subclinical or causes a self-limiting upper respiratory disease. However, in a small subset of patients IVI rapidly progresses to primary viral pneumonia (PVP) with respiratory failure; a minority of patients require intensive care unit admission. Inherited and acquired variability in host immune responses may influence susceptibility and outcome of IVI. However, the molecular basis of such human factors remains largely elusive. It has been proposed that homozygosity for IFITM3 rs12252-C is associated with a population-attributable risk of 5.4 % for severe IVI in Northern Europeans and 54.3 % for severe H1N1pdm infection in Chinese. A total of 148 patients with confirmed IVI were considered for recruitment; 118 Spanish patients (60 of them hospitalized with PVP) and 246 healthy Spanish individuals were finally included in the statistical analysis. PCR-RFLP was used with confirmation by Sanger sequencing. The allele frequency for rs12252-C was found to be 3.5 % among the general Spanish population. We found no rs12252-C homozygous individuals in our control group. The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza. Our data do not suggest a role of rs12252-C in the development of severe IVI in our population. These data may be relevant to recognize whether patients homozygous for rs12252-C are at risk of severe influenza, and hence require individualized measures in the case of IVI.
DOI: 10.1007/s10096-016-2732-7
PubMed: 27492307
PubMed Central: PMC7100079
Affiliations:
Links toward previous steps (curation, corpus...)
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L Pez-Rodríguez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Clinical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Clinical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Herrera Ramos, E" sort="Herrera Ramos, E" uniqKey="Herrera Ramos E" first="E" last="Herrera-Ramos">E. 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Borderías</name><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital San Jorge, Huesca, 22004, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital San Jorge, Huesca, 22004</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author><author><name sortKey="Horcajada, J P" sort="Horcajada, J P" uniqKey="Horcajada J" first="J P" last="Horcajada">J P Horcajada</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Hospital del Mar de Investigaciones Médicas (IMIM), CIBERES, Barcelona, 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar de Investigaciones Médicas (IMIM), CIBERES, Barcelona, 08003</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lerma Chippirraz, E" sort="Lerma Chippirraz, E" uniqKey="Lerma Chippirraz E" first="E" last="Lerma-Chippirraz">E. Lerma-Chippirraz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rajas, O" sort="Rajas, O" uniqKey="Rajas O" first="O" last="Rajas">O. Rajas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, 28005, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, 28005</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Briones, M" sort="Briones, M" uniqKey="Briones M" first="M" last="Briones">M. Briones</name><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital Clínico y Universitario de Valencia, Valencia, 46010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital Clínico y Universitario de Valencia, Valencia, 46010</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Perez Gonzalez, M C" sort="Perez Gonzalez, M C" uniqKey="Perez Gonzalez M" first="M C" last="Pérez-González">M C Pérez-González</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Microbiology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Garcia Bello, M A" sort="Garcia Bello, M A" uniqKey="Garcia Bello M" first="M A" last="García-Bello">M A García-Bello</name><affiliation wicri:level="2"><nlm:affiliation>Department of Statistics, Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Statistics, Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="L Pez Granados, E" sort="L Pez Granados, E" uniqKey="L Pez Granados E" first="E" last="L Pez-Granados">E. L Pez-Granados</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital La Paz, La Paz Institute of Biomedical Research, IdiPAZ, Madrid, 28046, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital La Paz, La Paz Institute of Biomedical Research, IdiPAZ, Madrid, 28046</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rodriguez De Castro, F" sort="Rodriguez De Castro, F" uniqKey="Rodriguez De Castro F" first="F" last="Rodriguez De Castro">F. Rodriguez De Castro</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Rodriguez Gallego, C" sort="Rodriguez Gallego, C" uniqKey="Rodriguez Gallego C" first="C" last="Rodríguez-Gallego">C. Rodríguez-Gallego</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital Universitario Son Espases, Palma de Mallorca, 07120, Spain. josecarlos.rodriguezgallego@ssib.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Son Espases, Palma de Mallorca, 07120</wicri:regionArea><placeName><region nuts="2" type="communauté">Îles Baléares</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hospital Universitario Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain. josecarlos.rodriguezgallego@ssib.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27492307</idno><idno type="pmid">27492307</idno><idno type="doi">10.1007/s10096-016-2732-7</idno><idno type="pmc">PMC7100079</idno><idno type="wicri:Area/Main/Corpus">00123</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00123</idno><idno type="wicri:Area/Main/Curation">000123</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000123</idno><idno type="wicri:Area/Main/Exploration">000123</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">IFITM3 and severe influenza virus infection. No evidence of genetic association.</title><author><name sortKey="L Pez Rodriguez, M" sort="L Pez Rodriguez, M" uniqKey="L Pez Rodriguez M" first="M" last="L Pez-Rodríguez">M. L Pez-Rodríguez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Clinical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Clinical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Herrera Ramos, E" sort="Herrera Ramos, E" uniqKey="Herrera Ramos E" first="E" last="Herrera-Ramos">E. Herrera-Ramos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Sole Violan, J" sort="Sole Violan, J" uniqKey="Sole Violan J" first="J" last="Solé-Violán">J. Solé-Violán</name><affiliation wicri:level="2"><nlm:affiliation>Intensive Care Unit, Hospital Universitario de Gran Canaria Dr. Negrín, CIBERES, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Intensive Care Unit, Hospital Universitario de Gran Canaria Dr. Negrín, CIBERES, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Ruiz Hernandez, J J" sort="Ruiz Hernandez, J J" uniqKey="Ruiz Hernandez J" first="J J" last="Ruíz-Hernández">J J Ruíz-Hernández</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Borderias, L" sort="Borderias, L" uniqKey="Borderias L" first="L" last="Borderías">L. Borderías</name><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital San Jorge, Huesca, 22004, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital San Jorge, Huesca, 22004</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author><author><name sortKey="Horcajada, J P" sort="Horcajada, J P" uniqKey="Horcajada J" first="J P" last="Horcajada">J P Horcajada</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Hospital del Mar de Investigaciones Médicas (IMIM), CIBERES, Barcelona, 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital del Mar de Investigaciones Médicas (IMIM), CIBERES, Barcelona, 08003</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lerma Chippirraz, E" sort="Lerma Chippirraz, E" uniqKey="Lerma Chippirraz E" first="E" last="Lerma-Chippirraz">E. Lerma-Chippirraz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rajas, O" sort="Rajas, O" uniqKey="Rajas O" first="O" last="Rajas">O. Rajas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, 28005, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, 28005</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Briones, M" sort="Briones, M" uniqKey="Briones M" first="M" last="Briones">M. Briones</name><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital Clínico y Universitario de Valencia, Valencia, 46010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital Clínico y Universitario de Valencia, Valencia, 46010</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté valencienne</region></placeName></affiliation></author><author><name sortKey="Perez Gonzalez, M C" sort="Perez Gonzalez, M C" uniqKey="Perez Gonzalez M" first="M C" last="Pérez-González">M C Pérez-González</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Microbiology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Garcia Bello, M A" sort="Garcia Bello, M A" uniqKey="Garcia Bello M" first="M A" last="García-Bello">M A García-Bello</name><affiliation wicri:level="2"><nlm:affiliation>Department of Statistics, Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Statistics, Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="L Pez Granados, E" sort="L Pez Granados, E" uniqKey="L Pez Granados E" first="E" last="L Pez-Granados">E. L Pez-Granados</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital La Paz, La Paz Institute of Biomedical Research, IdiPAZ, Madrid, 28046, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital La Paz, La Paz Institute of Biomedical Research, IdiPAZ, Madrid, 28046</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rodriguez De Castro, F" sort="Rodriguez De Castro, F" uniqKey="Rodriguez De Castro F" first="F" last="Rodriguez De Castro">F. Rodriguez De Castro</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Respiratory Diseases, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Respiratory Diseases, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010</wicri:regionArea><placeName><region nuts="2" type="communauté">Canaries</region></placeName></affiliation></author><author><name sortKey="Rodriguez Gallego, C" sort="Rodriguez Gallego, C" uniqKey="Rodriguez Gallego C" first="C" last="Rodríguez-Gallego">C. Rodríguez-Gallego</name><affiliation wicri:level="2"><nlm:affiliation>Department of Immunology, Hospital Universitario Son Espases, Palma de Mallorca, 07120, Spain. josecarlos.rodriguezgallego@ssib.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Son Espases, Palma de Mallorca, 07120</wicri:regionArea><placeName><region nuts="2" type="communauté">Îles Baléares</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Hospital Universitario Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain. josecarlos.rodriguezgallego@ssib.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca</wicri:regionArea><wicri:noRegion>Palma de Mallorca</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</title><idno type="eISSN">1435-4373</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Female (MeSH)</term><term>Gene Frequency (MeSH)</term><term>Genetic Predisposition to Disease (MeSH)</term><term>Genotyping Techniques (MeSH)</term><term>Humans (MeSH)</term><term>Influenza, Human (genetics)</term><term>Male (MeSH)</term><term>Membrane Proteins (genetics)</term><term>Middle Aged (MeSH)</term><term>Polymerase Chain Reaction (MeSH)</term><term>Polymorphism, Restriction Fragment Length (MeSH)</term><term>RNA-Binding Proteins (genetics)</term><term>Sequence Analysis, DNA (MeSH)</term><term>Spain (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Analyse de séquence d'ADN (MeSH)</term><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Fréquence d'allèle (MeSH)</term><term>Grippe humaine (génétique)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Polymorphisme de restriction (MeSH)</term><term>Protéines de liaison à l'ARN (génétique)</term><term>Protéines membranaires (génétique)</term><term>Prédisposition génétique à une maladie (MeSH)</term><term>Réaction de polymérisation en chaîne (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Techniques de génotypage (MeSH)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Proteins</term><term>RNA-Binding Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Grippe humaine</term><term>Protéines de liaison à l'ARN</term><term>Protéines membranaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genotyping Techniques</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Restriction Fragment Length</term><term>Sequence Analysis, DNA</term><term>Spain</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Espagne</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Polymorphisme de restriction</term><term>Prédisposition génétique à une maladie</term><term>Réaction de polymérisation en chaîne</term><term>Sujet âgé</term><term>Techniques de génotypage</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza virus infection (IVI) is typically subclinical or causes a self-limiting upper respiratory disease. However, in a small subset of patients IVI rapidly progresses to primary viral pneumonia (PVP) with respiratory failure; a minority of patients require intensive care unit admission. Inherited and acquired variability in host immune responses may influence susceptibility and outcome of IVI. However, the molecular basis of such human factors remains largely elusive. It has been proposed that homozygosity for IFITM3 rs12252-C is associated with a population-attributable risk of 5.4 % for severe IVI in Northern Europeans and 54.3 % for severe H1N1pdm infection in Chinese. A total of 148 patients with confirmed IVI were considered for recruitment; 118 Spanish patients (60 of them hospitalized with PVP) and 246 healthy Spanish individuals were finally included in the statistical analysis. PCR-RFLP was used with confirmation by Sanger sequencing. The allele frequency for rs12252-C was found to be 3.5 % among the general Spanish population. We found no rs12252-C homozygous individuals in our control group. The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza. Our data do not suggest a role of rs12252-C in the development of severe IVI in our population. These data may be relevant to recognize whether patients homozygous for rs12252-C are at risk of severe influenza, and hence require individualized measures in the case of IVI.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27492307</PMID><DateCompleted><Year>2017</Year><Month>02</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-4373</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>11</Issue><PubDate><Year>2016</Year><Month>Nov</Month></PubDate></JournalIssue><Title>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</Title><ISOAbbreviation>Eur. J. Clin. Microbiol. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>IFITM3 and severe influenza virus infection. No evidence of genetic association.</ArticleTitle><Pagination><MedlinePgn>1811-1817</MedlinePgn></Pagination><Abstract><AbstractText>Influenza virus infection (IVI) is typically subclinical or causes a self-limiting upper respiratory disease. However, in a small subset of patients IVI rapidly progresses to primary viral pneumonia (PVP) with respiratory failure; a minority of patients require intensive care unit admission. Inherited and acquired variability in host immune responses may influence susceptibility and outcome of IVI. However, the molecular basis of such human factors remains largely elusive. It has been proposed that homozygosity for IFITM3 rs12252-C is associated with a population-attributable risk of 5.4 % for severe IVI in Northern Europeans and 54.3 % for severe H1N1pdm infection in Chinese. A total of 148 patients with confirmed IVI were considered for recruitment; 118 Spanish patients (60 of them hospitalized with PVP) and 246 healthy Spanish individuals were finally included in the statistical analysis. PCR-RFLP was used with confirmation by Sanger sequencing. The allele frequency for rs12252-C was found to be 3.5 % among the general Spanish population. We found no rs12252-C homozygous individuals in our control group. The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza. Our data do not suggest a role of rs12252-C in the development of severe IVI in our population. These data may be relevant to recognize whether patients homozygous for rs12252-C are at risk of severe influenza, and hence require individualized measures in the case of IVI.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>López-Rodríguez</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrera-Ramos</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solé-Violán</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, Hospital Universitario de Gran Canaria Dr. Negrín, CIBERES, Las Palmas de Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruíz-Hernández</LastName><ForeName>J J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borderías</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Respiratory Diseases, Hospital San Jorge, Huesca, 22004, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horcajada</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital del Mar de Investigaciones Médicas (IMIM), CIBERES, Barcelona, 08003, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerma-Chippirraz</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Hospital Universitari del Mar, Barcelona, 08003, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajas</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Respiratory Diseases, Hospital Universitario de la Princesa, Madrid, 28005, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briones</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Respiratory Diseases, Hospital Clínico y Universitario de Valencia, Valencia, 46010, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pérez-González</LastName><ForeName>M C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Bello</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Statistics, Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Granados</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hospital La Paz, La Paz Institute of Biomedical Research, IdiPAZ, Madrid, 28046, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez de Castro</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences, School of Medicine, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Respiratory Diseases, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Gallego</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Immunology, Hospital Universitario Son Espases, Palma de Mallorca, 07120, Spain. josecarlos.rodriguezgallego@ssib.es.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology, Hospital Universitario Son Espases, Carretera de Valldemossa 79, 07120, Palma de Mallorca, Spain. josecarlos.rodriguezgallego@ssib.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Clin Microbiol Infect Dis</MedlineTA><NlmUniqueID>8804297</NlmUniqueID><ISSNLinking>0934-9723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C080082">IFITM3 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060005" MajorTopicYN="N">Genotyping Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012150" MajorTopicYN="N">Polymorphism, Restriction Fragment Length</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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name="Espagne"><region name="Canaries"><name sortKey="L Pez Rodriguez, M" sort="L Pez Rodriguez, M" uniqKey="L Pez Rodriguez M" first="M" last="L Pez-Rodríguez">M. L Pez-Rodríguez</name></region><name sortKey="Borderias, L" sort="Borderias, L" uniqKey="Borderias L" first="L" last="Borderías">L. Borderías</name><name sortKey="Briones, M" sort="Briones, M" uniqKey="Briones M" first="M" last="Briones">M. Briones</name><name sortKey="Garcia Bello, M A" sort="Garcia Bello, M A" uniqKey="Garcia Bello M" first="M A" last="García-Bello">M A García-Bello</name><name sortKey="Herrera Ramos, E" sort="Herrera Ramos, E" uniqKey="Herrera Ramos E" first="E" last="Herrera-Ramos">E. Herrera-Ramos</name><name sortKey="Herrera Ramos, E" sort="Herrera Ramos, E" uniqKey="Herrera Ramos E" first="E" last="Herrera-Ramos">E. Herrera-Ramos</name><name sortKey="Horcajada, J P" sort="Horcajada, J P" uniqKey="Horcajada J" first="J P" last="Horcajada">J P Horcajada</name><name sortKey="Horcajada, J P" sort="Horcajada, J P" uniqKey="Horcajada J" first="J P" last="Horcajada">J P Horcajada</name><name sortKey="L Pez Granados, E" sort="L Pez Granados, E" uniqKey="L Pez Granados E" first="E" last="L Pez-Granados">E. L Pez-Granados</name><name sortKey="L Pez Rodriguez, M" sort="L Pez Rodriguez, M" uniqKey="L Pez Rodriguez M" first="M" last="L Pez-Rodríguez">M. L Pez-Rodríguez</name><name sortKey="Lerma Chippirraz, E" sort="Lerma Chippirraz, E" uniqKey="Lerma Chippirraz E" first="E" last="Lerma-Chippirraz">E. Lerma-Chippirraz</name><name sortKey="Perez Gonzalez, M C" sort="Perez Gonzalez, M C" uniqKey="Perez Gonzalez M" first="M C" last="Pérez-González">M C Pérez-González</name><name sortKey="Rajas, O" sort="Rajas, O" uniqKey="Rajas O" first="O" last="Rajas">O. Rajas</name><name sortKey="Rodriguez De Castro, F" sort="Rodriguez De Castro, F" uniqKey="Rodriguez De Castro F" first="F" last="Rodriguez De Castro">F. Rodriguez De Castro</name><name sortKey="Rodriguez De Castro, F" sort="Rodriguez De Castro, F" uniqKey="Rodriguez De Castro F" first="F" last="Rodriguez De Castro">F. Rodriguez De Castro</name><name sortKey="Rodriguez Gallego, C" sort="Rodriguez Gallego, C" uniqKey="Rodriguez Gallego C" first="C" last="Rodríguez-Gallego">C. Rodríguez-Gallego</name><name sortKey="Rodriguez Gallego, C" sort="Rodriguez Gallego, C" uniqKey="Rodriguez Gallego C" first="C" last="Rodríguez-Gallego">C. Rodríguez-Gallego</name><name sortKey="Ruiz Hernandez, J J" sort="Ruiz Hernandez, J J" uniqKey="Ruiz Hernandez J" first="J J" last="Ruíz-Hernández">J J Ruíz-Hernández</name><name sortKey="Sole Violan, J" sort="Sole Violan, J" uniqKey="Sole Violan J" first="J" last="Solé-Violán">J. Solé-Violán</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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